Objective: This prospective cohort study was designed to assess the rule of myocardial performance\n(Tei) index and NT-Pro BNP serum levels in prediction of weaning failure in mechanically\nventilated COPD patients. Methods: Forty patients with respiratory failure due to acute exacerbation\nof COPD were enrolled to this study. All patients underwent a comprehensive echocardiographic\nexamination including tissue doppler imaging within first 12 hours of admission. NT-pro\nBNP serum levels were measured on admission. Patients were followed up for outcome of weaning\nfailure. Results: Right ventricular Tei index was higher in patients with failed weaning in comparison\nto successfully weaned patients (mean 0.66 versus 0.36, P < 0.001), also left ventricular Tei\nindex was higher in patients who failed to be weaned (mean 0.45 versus 0.36, P = 0.007). There\nwas no difference in serum NT-Pro BNP between successfully weaned patients and patients with\nweaning failure. Right ventricular Tei index showed higher accuracy in predicting weaning failure\nthan the left ventricular Tei index (AUC 0.932 versus 0.754), while serum NT-Pro BNP showed no\ndiscrimination in predicting weaning failure (AUC 0.556). Conclusion: Tei index was superior to\nNT-ProBNP in prediction of weaning failure in COPD patients.
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